Hyderabad: Cryo- electron microscopy ushered in at CSIR-CCMB
Hyderabad: An innovative center for cryo-electron microscopy was ushered in by Dr Shekhar Mande, Director-General, Council of Scientific and also Industrial Research (CSIR), at the Centre for Cellular and also Molecular Biology (CCMB) on Friday.
A launch claimed, with this center, Hyderabad is the 2nd city in the country to organize a contemporary cryo-electron microscopy center. Such a center enables researchers to take a look at the issue to its atomic information. A close take a look at particles, such as healthy proteins, has actually gone to the center of recognizing the architectural information of living cells and also medicine exploration.
In the last 2 years, such understandings have actually made it possible for researchers and also pharmaceutical markets to recognize the Corona infection and also locate possible remedies. “The modern cryo-electron microscopy facility is expected to help us view the functioning of several molecular machines that operate in the cell that was earlier not amenable to conventional structure determination methods such as X-ray crystallography or Nuclear Magnetic Resonance (NMR),” claimed Dr Rajan Sankaranarayanan, a noteworthy architectural biologist at CCMB.
“The facility on CCMB’s campus is funded by the CSIR. It will be accessible to researchers in CCMB, other CSIR labs as well as in other research institutes and universities. It will also be available to the biotech and pharmaceutical industries, of which Hyderabad is a major hub. The facility has been largely built in CCMB in the last two years during Covid pandemic, thanks to our in-house teams,” claimed Dr Vinay K Nandicoori, Director, CCMB. This center will certainly enable collaborating with examples at cryogenic temperature levels, around -173 levels C, and also photographing specific particles utilizing the electron microscopic lense. This, along with the confocal microscopy, NMR spectroscopy and also X-ray diffraction centers at CCMB, makes it an awesome center for scientists to consider information of living cells like never ever previously.
“Structural biology techniques have advanced greatly in the last four decades. From needing a year to collect and make sense of each data point to doing it in a few seconds now, the power is enormous.
The chasm between structural and cellular biology is diminishing, and this will allow addressing some of the very fundamental and exciting problems of biology with techniques like cryo-electron microscopy,” claimed Dr Shekhar Mande, Director-General, CSIR.